loader image
Tuesday, October 3, 2023
79.3 F
We Welcome your Press Release
- Advertisement -

Creating a Bioartificial Kidney as a Permanent Solution to Kidney Failure

Translate to Spanish or other 102 languages!

Shuvo Roy, PhD, holding a prototype of the bioartificial kidney. Photo by Steve Babuljak, University of California San Francisco

Mega Doctor News

- Advertisement -

University of California San Francisco

Shuvo Roy, PhD. -Photo by University of California San Francisco

The Kidney Project national research team is being led by Shuvo Roy, PhD, a bioengineer and faculty member in the Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco (UCSF). The project is co-directed by William Fissell, MD, at Vanderbilt University Medical Center.

The team is developing a surgically implanted, free-standing bioartificial kidney to perform the vast majority of the filtration, balancing, and other biological functions of the natural kidney. The two-part device leverages recent developments in silicon nanotechnology, membrane filtration, and cell science. It is powered by the body’s own blood pressure without the need for external tubes and tethers or immunosuppressant drugs.

- Advertisement -

UCSF is the appropriate home base for the project. It’s known worldwide as an institution that attacks biomedical problems with the kind of interdisciplinary zeal required to carry forward an effort this bold. And UCSF has made The Kidney Project a campus research priority.

William Fissell, MD. -Photo by Vanderbilt University

The need for a new kidney failure treatment option is great and growing, and the timeline therefore is ambitious. The Kidney Project team anticipates first-in-human clinical trials in a couple of years.

Miniaturizing the extracorporeal Renal Assist Device

The implantable bioartificial kidney builds upon the existing extracorporeal Renal Assist Device (RAD), which is a bioartificial kidney that combines a membrane hemofilter and a bioreactor of human renal tubule cells to mimic many of the metabolic, endocrine, and immunological functions of a healthy kidney.

- Advertisement -

While clinical trials confirmed that the RAD can safely treat acute renal failure in a critical care setting, adoption of the RAD for routine treatment of kidney failure patients is hampered by its labor-intensive and complex operation, large size, and high marginal cost.

The ultimate goal of The Kidney Project is to apply microelectromechanical systems (MEMS) and nanotechnology to miniaturize the extracorporeal RAD into a surgically implantable, self-monitoring, and self-regulating bioartificial kidney.

After a single surgery to establish a permanent blood connection, the bioartificial kidney processes blood continuously for 24 hours per day, which mitigates the inconveniences and morbidities associated with intermittent hemodialysis.

There are several benefits to the implantable bioartificial kidney including the alleviation of the necessity of constant physician oversight and a heavy regimen of immunosuppressant drugs and medication.

Leveraging recent advances in science

To mimic the work of a natural kidney, the bioartificial kidney has to contain high efficiency ultrafiltration membranes, be able to regulate blood flow, and stabilize necessary cells within an engineered environment.

Three key technology developments were needed to implement these functions:

high-efficiency ultrafiltration membranes,

control of blood-materials interactions such as thrombosis and fouling, and

stable differentiated function of renal cells in an engineered construct.

Advances in silicon nanotechnology were required to make it possible to mass-produce reliable, high-porosity, robust, and compact membranes. Improvements in molecular coatings that impart blood compatibility and techniques to coat silicon membranes without blocking pores were needed. And cell sourcing and storage issues had to be resolved. All of these technologies are now in place.

Two components: hemofilter and cell bioreactor

Our hemofilter uses silicon nanotechnology to produce a highly efficient and compact membrane, which relies on the body’s blood pressure to perform filtration without needing pumps or a power supply. The hemofilter must be capable of generating meaningful ultrafiltration volumes at driving pressures similar to capillary perfusion pressure, while remaining free of fouling for months. Furthermore, if this technology is to be generalized to implantable continuous therapies, protein losses must be minimal.

For the cell bioreactor, we are applying recent advances in the field of tissue engineering to grow and maintain renal tubule cells. The bioreactor must be capable of high-volume salt and water reabsorption from the ultrafiltrate while maintaining a barrier to reabsorption of toxins. In addition, it should impart biological activity such as autoregulation of blood pressure and production of vitamin D.

Miniaturization challenges

Early in our design process we identified two major obstacles to miniaturizing the RAD: size and pump requirements of modern dialysis units, and water volume needed for dialysis.

At the same time, we were inspired by the success of hollow fiber polymer membranes used in treating renal failure extracorporeally. However, we noticed that the kidney’s natural fibers were uniform, elongated, slit-shaped structures, rather than the irregular and more cylindrically shaped pores of polymer membranes. Our team has applied MEMS technology for the production of silicon nanopore membranes with slit-shaped pores that are tailored for implementation in a bioartificial kidney.


- Advertisement -
- Advertisement -

- Advertisement -

More Articles

World Leaders Commit to New Targets to End Tuberculosis

The targets include reaching 90% of people with TB prevention and care services, using a WHO-recommended rapid test as the first method of diagnosing TB; providing social benefit packages to all people with TB; licensing at least one new TB vaccine; and closing funding gaps for TB implementation and research by 2027. 

A Milestone for Community Health: Texas Mission of Mercy RGV Successfully Hosts Inaugural Free Dental Clinic

The seriousness of the dental health crisis in South Texas, an area with a population of about 870,000 and significant poverty rates, wasn't lost on the organizers.

DHR Health Transplant Institute Welcomes Dr. Jose Luis Valdes, Transplant Nephrologist

“It is with great pleasure that we welcome Dr. Valdes to our DHR Health Transplant Institute,” said Marissa Castañeda, Senior Executive Vice President at DHR Health.

Texas Mission of Mercy in Hidalgo County is a Collaborative Effort between community Leaders, Volunteers, and Dental Professionals

It was an event defined by community, compassion, and a relentless quest for public welfare.
- Advertisement -