loader image
Wednesday, December 10, 2025
59.6 F
McAllen
- Advertisement -

Largest Study of COVID-19 Vaccine Skin Reactions Shows a Wide Range of Reactions Possible — but None Severe

Translate to Spanish or other 102 languages!

Image for illustration purposes only

Mega Doctor News

- Advertisement -

Newswise — ROSEMONT, Ill. — As COVID-19 vaccination ramps up globally, new research published today in the Journal of the American Academy of Dermatology demonstrates the wide variety of skin rashes, including full-body rashes, observed after COVID-19 vaccination. The authors provide reassurance that these reactions are generally mild, resolve on their own, and should not deter the public from getting vaccinated.

“We understand that some of these reactions may look scary, but when they appear more than four hours after receiving the COVID-19 vaccine, they are typically minor and in some cases, may indicate the body’s immune system is doing a good job of responding to the vaccine,” says senior study author and board-certified dermatologist Esther Freeman, MD, PhD, FAAD, director of Global Health Dermatology at Massachusetts General Hospital and principal investigator of the international COVID-19 Dermatology Registry. “Some rashes may appear a day or two after vaccination, and some have a delayed onset, as long as 7-14 days after vaccination. Most of these rashes resolve on their own with time or — depending on the rash — may require oral antihistamines, topical steroids, or other treatments as directed by a physician.” 

Dr. Freeman does note that any reactions that start immediately after vaccination, or within four hours of the shot, need to be taken very seriously, and patients experiencing these rare type of allergic symptoms should seek prompt medical attention, as recommended by the CDC.

- Advertisement -

Dr. Freeman’s research examined the Moderna and Pfizer vaccines — two of the most widely administered vaccines authorized for emergency use by the FDA — in the U.S. from December 2020 to February 2021. The research of 414 skin reactions logged in the COVID-19 Dermatology Registry from healthcare workers, including board-certified dermatologists, identified a broad range of skin reactions. These include 218 cases of large, delayed reactions near the injection site — dubbed “COVID vaccine arm” — as well as other types of rashes that include rashes at the injection spot, hives, and full-body rashes similar to those typically seen after viral infections. 

Dr. Freeman also says that some patients have developed pernio/chilblains, or what has been called “COVID toes”, following COVID-19 vaccines. She notes that this is of particular interest because it shows that the vaccine is triggering a similar immune response as can be seen after the virus. While these reactions are uncomfortable, she says, they are not necessarily a bad thing. It shows that your body is mounting an immune response to the vaccine, she says, which, in some cases, shows up on your skin.

“As dermatologists, we view the skin as a window into what is happening elsewhere in your body,” says Dr. Freeman. “Through this research, we have a deeper understanding of how the COVID-19 vaccine affects our patients and their skin, and I hope our findings, which show that people tolerated vaccination well even when they did develop skin side effects, offer greater reassurance for anyone who is hesitant to get vaccinated.”

In addition to studying a large spectrum of skin reactions to the COVID-19 vaccines, the researchers assessed patients’ responses from the first dose to the second. They found that less than half of the people who experienced skin reactions after the first dose experienced a reaction after the second, and if they did, it was milder.

- Advertisement -

“I hope this information encourages more people to get their second dose of the COVID-19 vaccine even if they experienced a skin reaction after their first dose,” says Dr. Freeman. “The COVID-19 vaccine will help protect you from getting the virus and can also prevent you from getting very sick if you do get infected.”

If you have concerns about a rash or other skin reaction that develops after getting the COVID-19 vaccine, don’t hesitate to call your doctor or a board-certified dermatologist.To find a board-certified dermatologist in your area, visit aad.org/findaderm

- Advertisement -
- Advertisement -

- Advertisement -

More Articles

STHS Edinburg Named to Forbes’ 2026 Top Hospitals List

South Texas Health System (STHS) Edinburg has been named to the 2026 Forbes list of America's Top Hospitals. The facility is one of only 253 of the more than 5,400 eligible hospitals nationwide to earn a 5-star rating, including only 13 in Texas.

Blanket & Heater Drive for Elderly RGV Residents thru Dec. 31st

The coldest time of the year in South Texas is right around the corner, with overnight lows in the 40s and 50s Fahrenheit predicted during the region’s mild winter season from late December through mid-February and occasional cold fronts bringing brief dips below freezing.

‘Troopers, Toys & Teddy Bears’ Holiday Drive, Thru Dec. 21st

Mega Doctor News For millions around the world, the Christmas season is considered “the most...

STHS McAllen Hosting 40th Anniversary Community Celebration, Dec. 11th

For the last 40 years, South Texas Health System (STHS) McAllen has stood tall in the South Texas skyline, serving as a beacon of healing and hope for the residents of McAllen and the greater Rio Grande Valley.
- Advertisement -
×