loader image
Wednesday, April 17, 2024
92.2 F
McAllen
We Welcome your Press Release
- Advertisement -

Common Weight-Loss Drug Successfully Targets Fat That Can Endanger Heart Health

Translate to Spanish or other 102 languages!

UT Southwestern Medical Center
Parag Joshi, M.D., preventive cardiologist

Mega Doctor News

- Advertisement -

by UT Southwestern Medical Center

Newswise — DALLAS – August 4, 2021 – Researchers at UT Southwestern announced successful results of a clinical trial for a commonly prescribed weight-loss drug called liraglutide. In adults who are overweight or have obesity combined with high cardiovascular risk, once-daily liraglutide combined with lifestyle interventions significantly lowered two types of fat that have been associated with risk to heart health: visceral fat and ectopic fat.

“Our study used the latest imaging technology to evaluate different fat components in the body. The main finding was a significant decrease in visceral fat in patients without diabetes but who were overweight or had obesity. These results show the potential of liraglutide treatment for significantly lowering the risk of chronic disease in this population,” said Parag Joshi, M.D., preventive cardiologist, Assistant Professor of Cardiology, and senior author of the study published in The Lancet Diabetes & Endocrinology.

- Advertisement -

Visceral fat is stored within the abdominal cavity around important internal organs, such as the liver, pancreas, and intestines. Ectopic fat is stored in tissues that normally contain small amounts of fat, such as the liver, skeletal muscle, heart, and pancreas.

The 185 study participants were given a once-daily injection of liraglutide over 40 weeks of treatment. The relative effects of liraglutide on fat reduction were two-fold greater in the abdominal tissues and six-fold greater in the liver than seen on overall body weight. The treatment effect was consistent across race/ethnicity and BMI categories, and among those with or without baseline prediabetes. Liraglutide also reduced fasting blood glucose and inflammation in this trial population without diabetes, the majority of whom had normal blood sugar levels at baseline.

In a 2016 study led by UTSW investigators called the Leader trial, the rate of the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke among patients with type 2 diabetes was lower in those treated with liraglutide than with placebo. “Our findings help add a possible mechanism for why there is a benefit of liraglutide on cardiovascular outcomes while also showing its benefits in people without diabetes,” said Dr. Joshi.

According to the researchers, obesity affects an estimated 1 in every 4 adults and 1 in every 5 youths, leading to substantial risk of cardiovascular disease and mortality. “Excess visceral fat and ectopic (e.g., liver) fat are central to the development of type 2 diabetes and cardiovascular disease,” said Dr. Joshi. “It remains challenging to identify those at highest risk, in order to offer them treatment in addition to lifestyle changes such as diet and exercise.”

- Advertisement -

The study was funded by an investigator-initiated grant from Novo Nordisk.

Other UT Southwestern researchers who contributed to the study include Colby R. Ayers, Bienka Lewis, Robert Oslica, Susan Rodder, and Ambarish Pandey.

UT Southwestern is nationally ranked No. 11 in Cardiology and Heart Surgery and No. 24 in Diabetes and Endocrinology in U.S. News & World Report’s 2021-22 Best Hospitals survey.

- Advertisement -
- Advertisement -

- Advertisement -

More Articles

DHR Health Hosts Achieving Wellness Seminar at ECCR

The "Achieving Your Wellness Plan in 2024" seminar was recently hosted by the DHR Health Oncology Institute from 9:00 a.m. to noon on April 13, 2024, at the Edinburg Conference Center at Renaissance.

STC to host Emerging Scientist Symposium, April 18th 

STC students, faculty, staff and the community are welcome to attend the symposium and engage in the presentations and discussions to witness firsthand how the psychological science discipline and other sciences converge and contribute to our daily lives. 

Financial Planning Workshop for Expecting Moms in Rio Grande City, April 17th

Mega Doctor News Molina Healthcare of Texas will host a financial planning...

Hidalgo County Grand Opening for New Public Health Facility, April 18th

Equipped with cutting-edge technology, the facility shall include a SARS-CoV2 testing and testing of other virology diseases through the use of nucleic acid assay (i.e. PCR machine).
- Advertisement -
×