loader image
Thursday, March 30, 2023
78.1 F
McAllen
We Welcome your Press Release
- Advertisement -

Type of early-onset dementia now more detectible

Translate to Spanish or other 102 languages!

Based on patient data from the University’s FRONTIER Research Group (dementia research), to which Dr Foxe belongs, and created in collaboration with the University’s School of Mathematics and Statistics, it can predict a PPA diagnosis with a sensitivity rate of 70 to 80 percent. Image for illustration purposes
Based on patient data from the University’s FRONTIER Research Group (dementia research), to which Dr Foxe belongs, and created in collaboration with the University’s School of Mathematics and Statistics, it can predict a PPA diagnosis with a sensitivity rate of 70 to 80 percent. Image for illustration purposes
- Advertisement -

Mega Doctor News

By University of Sydney

Newswise – With the recent announcement of Bruce Willis’ retirement due to aphasia, this spectrum of disorders has received increasing attention in the news and media – including a rare type of dementia known as primary progressive aphasia (PPA).

PPAs are rare, incurable, younger-onset dementias that primarily affect speech and language and occur in people between the ages of 50-70. They are complicated by the fact that there are three subtypes, each with distinct patterns of brain atrophy or shrinkage, brain pathologies, and prognoses. One common theme across all PPA variants is that they are difficult to diagnose in their early stages, leading to costly doctor visits and delayed treatments and care services.

- Advertisement -

new, free, online, clinician-administered tool developed by researchers and clinicians at the University of Sydney’s Brain and Mind Centre could greatly increase the likelihood of early PPA detection.

An explanation of the tool is published in Brain Communications

Drawing on a commonly used cognitive screening test, the Addenbrooke’s Cognitive Examination-III (ACE-III), Dr David Foxe led the development of the ACE-III PPA diagnostic calculator.

Based on patient data from the University’s FRONTIER Research Group (dementia research), to which Dr Foxe belongs, and created in collaboration with the University’s School of Mathematics and Statistics, it can predict a PPA diagnosis with a sensitivity rate of 70 to 80 percent.

- Advertisement -

This means with patients suspected to have PPA, the tool is able to differentiate the PPA variants between 70 and 80 percent of the time.

It would have been of great benefit to Jane Dean and her husband Stephen Dean, a FRONTIER research participant who was only diagnosed with PPA by FRONTIER after almost two years of doctor visits and tests. 

“Arriving at a diagnosis of PPA was arduous and stressful,” Mrs Dean said.

Being from Tumut, a town near Canberra at the foothills of the Snowy Mountains, made things more difficult, as the couple had to travel as far as Albury Wodonga and Sydney to seek specialist help.

“In a remote location like ours, it’s hard to feel supported. You’re isolated,” she said.

“Diagnosing the PPA variants is difficult as the language profiles are often complex, overlapping or difficult to detect for inexperienced clinicians,” Dr Foxe said. 

“However, it’s really important that PPA patients receive the correct diagnosis as this will ensure that they receive the right treatment. I hope my tool will improve the clinical assessment of PPA, especially in rural and primary health settings where dementia clinics are few and far between, and ultimately improve the lives of people living with this incurable disease.” 

Yet Dr Foxe cautioned that the tool should only be used when a person is suspected to have PPA and that a clinician should read the associated paper before administering it. 

About primary progressive aphasia

Over 30,000 Australians live with younger-onset dementia and about a quarter are diagnosed with PPA. 

The three subtypes of PPA are logopenic (difficulty speaking and finding the right words), non-fluent (difficulty articulating words) and semantic (comprehension loss).

Over time, other cognitive and functional abilities deteriorate, resulting in death approximately 7-12 years from diagnosis. PPA generally presents before the age of 65 years, significantly impacting family, vocational, social and community roles. 

It is caused by an abnormal build-up of proteins in the brain (especially near the language structures), resulting in a slow, progressive loss of brain cells. 

There is currently no cure for PPA but researchers at the University of Sydney are investigating the underlying pathological causes of these diseases – which could lead to novel pharmacological interventions.

In the meantime, treatments such as speech therapy have been found to alleviate symptoms and improve quality of life in the early disease stages. Recently, FRONTIER and the University’s Communication Disorders Treatment and Research Clinic have formed a partnership to provide student-led speech pathology clinical services to PPA patients and their families.

- Advertisement -
- Advertisement -

- Advertisement -

More Articles

Prevent Salmonella in Eggs

Always handle and cook eggs properly to prevent illness.

Lung Cancer Screening Rates Extremely Low 

Rates were higher but still extremely low for Original Medicare (3.4%) and Medicare Advantage (4.6%).

Life with Fibromyalgia

The cause of fibromyalgia is not known, but it can be effectively treated and managed.

New Technology Illuminates Bladder Cancer Detection

UC San Diego Health is one of only 33 locations in the nation able to offer this full continuum of care.
- Advertisement -
×