One Injection Stops Diabetes in Its Tracks

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Treatment reverses symptoms of type 2 diabetes in mice without side effects. 

Scientists at the Salk Institute’s Gene Expression Laboratory, led by Professor Ron Evans, have discovered the role of FGF1, a molecule which has been shown to regulate blood glucose levels.

One injection stops diabetes in its tracks
Image: Courtesy of the Salk Institute for Biological Studies

In the liver tissue of obese animals with type 2 diabetes, unhealthy, fat-filled cells are prolific (small white cells, panel A). After chronic treatment through FGF1 injections, the liver cells successfully lose fat and absorb sugar from the bloodstream (small purple cells, panel B) and more closely resemble cells of normal, non-diabetic animals.

One injection stops diabetes in its tracks
From left: Jae Myoung Suh, Annette Atkins, Michael Downes, Maryam Ahmadian, Ronald Evans and Ruth Yu of the Gene Expression Laboratory. Image: Courtesy of the Salk Institute for Biological Studies.
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